GHK-CU is supplied as a catalogued research material in 50mg and 100mg.
GHK-Cu is not a single self-defining solid-form name. Authoritative public records represent materially different peptide:copper ratios and counter-ion forms. No one formula, mass, CAS number or PubChem CID should be assigned to these catalogue variants until the specification and matching CoA establish the actual complex [1–3].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine copper complex, Copper peptide |
| Material category | Research Peptide |
| Sequence | H-GHK-OH |
| Molecular formula | C14H22CuN6O4 |
| Average molecular mass | 401.91 g/mol |
| CAS Registry Number | 89030-95-5 |
| PubChem CID | CID 135475195 |
| Structural features | A tripeptide (Gly-His-Lys) forming a square planar complex with a copper (II) ion. |
| Appearance | Blue lyophilised powder |
| Solubility | Readily soluble in water. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A naturally occurring copper complex found in human plasma, saliva, and urine. It has various biological roles, including wound healing, anti-inflammatory effects, and skin remodeling. Widely used in cosmetics.
Research background and published evidence
Published research
The literature supports copper-binding and coordination research involving the Gly-His-Lys tripeptide. Those chemical observations can guide identity and analytical-method work, provided the complex stoichiometry and form are defined [1–4].
Current scientific understanding
Component chemistry and studies of separately manufactured topical or preclinical materials do not establish systemic safety, efficacy, dosage, administration, cosmetic suitability, or equivalence for these catalogue vials. Copper content and free copper are batch attributes, not consequences of the product name [1–4].
No authorised systemic medicinal-product status is inferred. The batch documentation should separately verify peptide identity and content, total copper, Cu:GHK molar ratio, free copper, counter-ion and relevant elemental impurities.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Catalogue GHK-CU with unconfirmed peptide:copper stoichiometry and counter-ion | A defined 1:1 or 2:1 GHK–Cu reference complex with specified counter-ion |
| Structural distinction | The catalogue name alone does not define coordination ratio, charge or solid form | Stoichiometry, charge and form are explicitly assigned |
| Analytical implication | Requires orthogonal peptide identity, copper assay, Cu:GHK ratio, free-copper and counter-ion testing | Reference mass and registry identifiers apply only to the matching defined complex |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. 1:1 copper–tripeptide/prezatide-copper representation, CID 71587328.
- [2] PubChem. 2:1 GHK:copper representation, CID 133697840.
- [3] PubChem. Distinct GHK-Cu acetate representation, CID 162343861.
- [4] Pickart et al. Copper-binding properties of the Gly-His-Lys tripeptide (1980).
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
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